Studies in which animals are allowed to die without pain relief. Non-vertebrates, laboratory mice, and laboratory rats. Pain or distress in mice is commonly expressed by dramatic changes in activity level and behavior. B. Postoperative analgesia is not generally needed in rodents. ${ }_{36}^{87} \mathrm{Kr} \longrightarrow-0 \beta+$. B. Which Public Health Service (PHS) organization is responsible for monitoring organizational compliance with PHS Policy? The Animal Welfare Regulations require the IACUC to do what two things regarding alternatives? What best describes the oral gavage procedure? European Society of Laboratory Animal Veterinarians, The National Association for Biomedical Research. B. Remove the animal from the threat if safe to do so and contact the attending veterinarian or IACUC. D. They become less stringent. What is a safe bleed volume for a 20-gram mouse? C. A change in the specific objectives for the project B. Sponsors an accreditation program mandated by U.S. A. Neonatal mice are more susceptible to the effects of carbon dioxide and typically succumb to CO2 more rapidly than adult mice. APPROXIMATELY 685 INSTITUTIONS ARE IN NORTH AMERICA, 111 INSTITUTIONS IN EUROPE, 13 INSTITUTIONS IN LATIN AMERICA AND THE CARIBBEAN, C If an IACUC votes to suspend a protocol or animal activity, its decision cannot be overturned by any administrator at the organization (including the Institutional Official). AAALAC International promotes the responsible treatment of animals in science through a voluntary accreditation program. Which of the following is an example of refinement per the three Rs of Russell and Burch? A protocol submitted to the IACUC should If the IACUC determines that an activity must be halted, and if the organization accepts PHS funds or is registered with USDA as a research organization, any protocol suspension must be reported by the Institutional Official to, respectively OLAW and USDA. C Category D of the USDA report form applies to " animals upon which experiments, teaching, research, surgery, or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic, analgesic, or tranquilizing drugs were used. Those organizations that sell vertebrate animals for research, teaching, or testing. The campus' animal care program is also accredited by the International Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC). B. Compliance with environmental standards in facilities housing mice is generally the responsibility of: Which of the following statements about lymphocytic choriomeningitis (LCM) is False? Right on! A If investigators plan to contract with a commercial enterprise or other entity to produce custom antibodies, whether polyclonal or monoclonal, they must obtain approval from the IACUC. Therefore, it is unnecessary to remove fetuses for euthanasia after the dam is euthanized (AVMA Guidelines 2013). B. C. Before any use of the animals for the project begins. To conduct voluntary evaluations of institutional animal care and use programs. D. Supportive care and monitoring can be discontinued when the mice have recovered from anesthesia. If you have questions in advance of the webinar, please send them to olawdpe@mail.nih.gov. C. For rodents, individual postoperative care records are not usually maintained. Dogs, cats, and primates In the 1950s, the Professional Standards Committee of the Animal Care Panel (ACP), now the American Association for Laboratory Animal Science (AALAS), recognized a need for assuring the general public that laboratory animal research was conducted on a professional level, and that standard procedures were applied. D. Contact with wild mice in field studies is a risk for exposure to zoonotic diseases. A. They provide security for the occupant and can prevent entry by unauthorized individuals. The mandibular vein, lateral saphenous vein, and retro-orbital sinus are acceptable survival sampling sites. Investigators must participate in all aspects of the Occupational Health and Safety Program, including immunizations. One book, The Guide for the Care and Use of Laboratory Animals serves as the basic standard represented by AAALAC accreditation. Permission should be obtained from the IACUC and clinical administrators responsible for the area. Which of the following statements regarding the use of restraint on animals in a research study is FALSE? Fish and Wildlife Service (FWS) A. Which of the following is true of AAALAC International? D. Laboratory use of recombinant chemical agents for in vitro work. The NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules apply to which of the following types of experiments? What diameter spherical balloon will just support the total weight? Meet people who The attending veterinarian A public relations specialist is not part of this mandate. C. Commercial antibody enterprises are not required to follow PHS or USDA guidelines. An anesthetic overdose is an acceptable method. B. The exercise must take place outside the building. Background. Which of the following protocol changes require IACUC approval? D. 5 percent, Because they cannot vomit and are not prone to aspiration pneumonia, which of the following animals should not routinely be fasted prior to surgery? The Guide for the Care and Use of Agricultural Animals in Agricultural Research and Teaching (the Ag Guide). Lethal dose experiments in which animals are allowed to die without intervention. It requires annual reports from its accredited facilities C. It conducts site visits every 3 years D. It is a government - sponsored agency 16. C. Institutional Animal Care and Utilization Corps which of the following is true of aaalac international? Animal forms must be rewritten to solicit continued IACUC approval. AAALAC International. When animals are used, AAALAC works with institutions and researchers to serve as a bridge between progress and animal well-being. A. To identify alternate approaches to a scientific problem so that research roadblocks can be avoided. C A mandated IACUC function is to conduct reviews of the animal care and use program on a semiannual basis. A. If the incision site on the skin is disinfected with iodine or chlorhexidine compounds, hair clipping is not necessary. Which is a characteristic of microchips used to identify mice? To conduct voluntary evaluations of institutional animal care and use programs. A narrative summarizing experimental data that justifies the use of the proposed animal model. This concept represents the beginning of the effort to form an accreditation program for laboratory animal care and use. Which of the following best summarizes the information that must be provided when a database search is used to document a lack of alternatives? Research utilizing animals is a privilege, not a right, and the IACUC has the responsibility to ensure that research, testing, and educational activities involving the use of animals are performed according to the highest standards. The program started in 1965, when leading veterinarians and researchers organized the American Association for Accreditation of Laboratory Animal Care (AAALAC), as a private, nonprofit organization. The name change reflected the organizations recognition and expansion in other countries, and its commitment to enhancing life sciences and quality animal care around the world. C. Inoculation of recombinant infectious agents into animals B The use of carbon dioxide in cylinders (not from dry ice) is the current recommended method of rodent euthanasia (AVMA recommendations on euthanasia) using a 20% replacement rate for the volume of carbon dioxide/cage or container. A. Which of the following activities would place an animal in category E? The needle tip should be inserted behind the incisors. The Council conducts on-site visits and extensive evaluations, and provides ongoing advice to help organizations achieve and maintain accreditation. Which of the following sets of IACUC members are required by the AWA and/or PHS? D. The Office of Laboratory Animal Welfare (OLAW). D. Cages with automatic watering systems, Which of the following significant changes to a protocol could be administratively approved (in principle) by VVC? The skin should be disinfected around the incision site. D. Rodents and rabbits. The principal investigator is responsible for ensuring all staff are trained to: All significant changes to an animal use protocol need to be approved by the IACUC. B. Try BYJUS free classes today!No worries! B. Experimental criteria are the only determinants of the euthanasia method that is acceptable for an animal. AAALAC Accreditation demonstrates to funding agencies and the general public that the animal care provided goes beyond minimum regulatory requirements. Assist with writing the basic science portions of a grant application Which of the following is TRUE regarding the Animal Welfare Regulations and duplication of experiments? Which of the following is considered a minor change that would not require formal IACUC review and approval? Unnecessary duplication of animal experiments is not allowed. Those organizations that conduct wildlife research. The library service used to perform the search, the date of the search, and the key words used. B. D. Notify the Institutional Official. When picking up a mouse from a filter top cage, putting the wire bar lid sideways on the cage is helpful to: Reposition your grasp as you take the mouse out of the cage as it will tend to hold on to the wire bar lid. C. The animals and investigators only However, agricultural animals used in biomedical research may need to be housed according to the Guide while on study. hose organizations that accept Public Health Service (PHS) or National Science Foundation (NSF) funding. Which of the following statements is true regarding research antibody production? In 1996, AAALAC changed its name to the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC International). The correct dental formula of the mouse is: Which statement about the Occupational Health and Safety Program is false? If the investigator believes the event is due to misuse, mistreatment, or noncompliance, the details of the incident should be reported to the IACUC (or use another reporting method recommended by their organization), so that the incident can be reviewed and investigated (if warranted). The Association for Assessment and Accreditation of Laboratory Animal Care International, or AAALAC, is a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. The Guide for the Care and Use of Laboratory Animals provides: The basic information needed to develop an institutional occupational health and safety program. Shock due to low blood volume and anemia. Which of the following is true of the dog exercise program mandated by the AWR? Leading veterinarians and researchers organized the American Association for Accreditation of Laboratory Animal Care (AAALAC) in 1965, as a private, nonprofit organization. Which of the following statements is/are TRUE regarding preparation of a mouse for surgery? Institutional Animal Care and Use Committee A change from non-survival to survival surgery Withhold feed during at least 12 hours following surgery. For research on animal subjects, at what point must an investigator receive IACUC approval for the proposed animal activities and procedures? D. If an IACUC votes to suspend a protocol or animal activity, that decision can be overturned by any administrator at the organization. A. The program started in 1965, when leading veterinarians and researchers organized the American Association for Accreditation of Labo If the funds used to contract for custom antibody production are from the PHS, the IACUC should ascertain that the commercial enterprise has a current Animal Welfare Assurance with the PHS. Which of the following statements is/are true regarding illumination in rooms housing rodents? A. In the mouse, IP injection should proceed only after aspiration has shown that the needle is properly positioned. Permission should be obtained from the IACUC and clinical administrators responsible for the area. A public relations specialist, veterinarian, person who is not a scientist, and person who is not affiliated with the organization. In this edition, we will bring you up to speed on AO VET activities over the past five months. To provide an assurance by an information specialist that no alternative to the proposed animal model exists. D. Rabbits are not allowed to be used for antibody production. In addition, more than 60 prestigious scientific, educational and other professional organizations are members of AAALAC International.